Schedule an appointment with your healthcare provider if you: Though Ledderhose disease is rare, it can be very painful and frustrating. dupuytrens-society.org.uk/information/ledderhose-disease/, ncbi.nlm.nih.gov/pmc/articles/PMC2945849/, rarediseases.info.nih.gov/diseases/6873/ledderhose-disease, dupuytrens-society.org.uk/treatment/ledderhose-disease/, radiopaedia.org/articles/plantar-fibromatosis. Ledderhose disease (plantar fibromatosis) is a rare disease. DOI: Skalski M, et al. For example, type 1 diabetes causes extreme thirst, weight loss, and fatigue. Autoimmune diseases can affect many types of tissues and nearly any organ in your body. Is there anything that triggers your symptoms? Joint pain, fatigue, and rashes are among the most common symptoms. A record of your familys health history. Plantar Fibromatosis: Pathophysiology, Surgical and Nonsurgical Therapies: An Evidence-Based Review. People with Ledderhose disease may also have other conditions associated with the formation of excess fibrous connective tissue such as Dupuytren contracture, knuckle pads, or Peyronie disease. All rights reserved. sharing sensitive information, make sure youre on a federal MRI tends to be more accurate than x-ray or ultrasound, showing the full extent of the condition. In contrast to Dupuytren disease, flexion . When the communication from nerves to muscles is impaired, signals cant direct the muscles to contract. It may occur at any age, with the greatest prevalence at middle age and beyond. The exact cause of Ledderhose disease is unknown, but it would appear that genes and environment both have roles. However, most are chronic (meaning that they last a long time, if not a lifetime). We avoid using tertiary references. It is a similar condition to Dupytren's contracture which occurs in the hand causing flexion of the fingers. If surgery is performed, the biopsy is predominantly cellular and frequently misdiagnosed as fibrosarcoma. Up to half of people with Ledderhose disease also have Dupuytrens contracture. Patient organizations can help patients and families connect. Other things which could pre-dispose you to this condition include diabetes, plantar fasciitis and certain auto-immune diseases. It affects the plantar fascia, which is the thick layer of tissue ( ligament) that protects and supports the bottom of your foot. Clinics in diagnostic imaging (195). This connective tissue forms into lumps or nodules on the soles of the feet. Is type 2 diabetes, like type 1, an autoimmune disease? For instance, the Dupuytren Contracture Institute recommend the use of dimethyl sulfoxide (DMSO) in some cases of connective tissue disorders, applying it directly to the affected area. Youre more likely to have a recurrence if any of the following applies: Last medically reviewed on August 14, 2017, Even if a lump on the side of your foot isnt causing any pain or other symptoms, its important to have a doctor look at it. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event. It is rare, but nodules may appear on the toes, and the pressure from the nodules in the foot can cause the toes to contract. (2012). Ledderhose disease is a type of plantar fibromatosis characterized by the growth of hard and round or flattened nodules (lumps) on the soles of the feet. When gluten is in the small intestine, the immune system attacks this part of the gastrointestinal tract and causes inflammation. Almost every autoimmune disease has more than one name. The exact cause is unknown, which means there is also very little known about how to prevent it. Some medications. The disease is more common in middle-aged and older people, and it occurs much more often in men than in women. Autoimmune vasculitis happens when the immune system attacks blood vessels. The symptoms you have will depend on the body part (s) affected, such as: Joints, which can cause joint pain and stiffness. Your doctor can use your symptoms and other tests to confirm the diagnosis. Second, any treatments out there are systemic and, frankly, dangerous. Many autoimmune diseases are more common in women than in men. Less often, the disease gets worse slowly over time. Treatment depends on the severity and progress of the nodules. Plantar fibromatosis: Surgical approach of a giant bilateral case. Ledderhose Disease is an extremely rare condition and many facts about it are still unknown. Check this site often for new trials that become available. Overview Ledderhose disease is a rare condition that causes connective tissue to build up and create hard lumps on the bottoms of the feet. The immune system is involved, but not exactly like an autoimmune disease. A doctor will use tests, review your symptoms, and conduct a physical examination to reach a diagnosis. Ledderhose disease, sometimes called plantar fibromatosis or "Dupuytren's of the foot," is characterized by lumps called nodules on the underside of the foot. Ledderhose Disease - Long Term Effects of Radiotherapy Treatment. Many types of autoimmune diseases cause redness, swelling, heat, and pain, which are the signs and symptoms of inflammation. This treatment is also used for Dupuytrens contracture. Not every nodule on the foot is a sign of the condition, and different disorders will require altogether different therapies. Many people have reported gluten sensitivity, which isnt an autoimmune disease but can have similar symptoms such as diarrhea and abdominal pain. (Eds.) But according to the U.S. National Library of Medicine, about one in four people with the condition report tenderness, . Talk to a trusted doctor before choosing to participate in any clinical study. You have a family history of the condition. Thyroid hormones control the bodys energy usage, known as metabolism. Recently, new-onset autoimmune phenomena after COVID-19 vaccination have been reported increasingly (e.g. It seems all to ironic that my Ledderhose Disease (nodules under the skin of my arches) and Dupuytren's Disease (puckering in the palm, a cord in the palm and fingers pulling inward) has so many connections to Autoimmune Diseases. In later stages, your healthcare provider may refer you to a foot and ankle specialist. Because the incidence of autoimmune diseases is rising, researchers suspect environmental factors like infections and exposure to chemicals or solvents might also be involved. Common ones include lupus, rheumatoid arthritis, Crohns disease and ulcerative colitis. Dorset, Poole - Mr Jeremy Southgate. Celiac disease and non-celiac gluten sensitivity. Repeated trauma, long-term alcohol consumption, chronic liver disease, diabetes, and epilepsy have also been reported in association with this condition. These lumps can be painful, especially when you walk. Dupuytren's contracture Risk factors and possible causes, "OMIM Entry -% 126900 - DUPUYTREN CONTRACTURE", "The Vikings and Baron Dupuytren's disease", "Ledderhose Disease: plantar fibromatosis", "Dupuytren's Contracture and Plantar Fibromatosis", "Plantar Fibromatosis aka Ledderhose Disease - Foot Pain Explored", http://www.dupuytren-online.info/ASTRO_2006/Poster_Ledderhose_ASTRO_06.JPG, "The etiology, evaluation, and management of plantar fibromatosis", "Point-Counterpoint: Is Conservative Care The Best Approach For Plantar Fibromatosis? This condition is related to other connective tissue diseases, especially Dupuytrens contracture. Your immune system is made up of organs and cells meant to protect your body from bacteria, parasites, viruses and cancer cells. This results in inflammation and damage. It may also help prevent and avoid injuries to the feet. This astonishing percentage is a . We explain the different characteristics between Crohns disease and ulcerative colitis, which are both part of inflammatory bowel disease (IBD). It is named after Dr. Georg Ledderhose who detailed the disorder in 1894. The disease is included in several widely used lists of autoimmune disease and is shown here to ensure that a person visiting this page does not conclude that the disease was not considered. Click to Keep Reading de Souza DF, et al. People with Ledderhose disease have a few different options for treatment, including natural remedies. Other possible alternative therapies include iodine and copper, which DMSO helps the skin absorb. Whenever is possible, the conservative therapies are recommended. Symptoms include weight gain, sensitivity to cold, fatigue, hair loss, and swelling of the thyroid (goiter). The disease is also. A larger challenge is that no one knows the root biology of Dupuytren/Ledderhose/Peyronie disease - how it starts, or . It usually occurs before the age of 15 years. Hashimoto's disease can occur at any age but more commonly occurs during middle age. Even though it is benign, the local manifestations can be aggressive, leading to debilitating deformities and contractures of the toes. A qualified doctor is the only person who should diagnose this condition. (https://pubmed.ncbi.nlm.nih.gov/30774465/), Visitation, mask requirements and COVID-19 information, non-steroidal anti-inflammatory medications (NSAIDs), Thickening over the tops of your finger joints (. Radiation treatment can lower the risk of the disease coming back. And even when its successfully treated, it can come back. Thyroid, which might cause you to be tired, gain weight, or have muscle aches. Other factors that may increase your risk of developing Ledderhose include: To start, you might try wearing soft shoe inserts to relieve pressure on the lumps and pad your foot so it doesnt hurt as much when you walk. Advertising on our site helps support our mission. Some autoimmune diseases target only one organ. 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, (https://www.benaroyaresearch.org/what-is-bri/disease-information/autoimmune-diseases), (https://www.autoimmuneinstitute.org/7-risk-factors-for-autoimmune-disease/), (https://www.autoimmuneinstitute.org/resources/symptomlist/), (https://www.merckmanuals.com/home/immune-disorders/allergic-reactions-and-other-hypersensitivity-disorders/autoimmune-disorders), (https://www.niams.nih.gov/health-topics/autoimmune-diseases), (https://www.womenshealth.gov/a-z-topics/autoimmune-diseases), Visitation, mask requirements and COVID-19 information. Usually, the immune system can tell the difference between foreign cells and your own cells. [5] The nodules are typically slow growing[2][5] and most often found in the central and medial portions of the plantar fascia. As in most forms of fibromatosis, it is usually benign and its onset varies with each patient. What is Autoimmune Disease? There does not seem to be any specific diet that will help prevent the disorder. The inflammation that results narrows the arteries and veins, allowing less blood to flow through them. The disease is also called Morbus Ledderhose. Surgical treatment of a case of Ledderhoses disease: A safe plantar approach to subtotal fasciectomy. Deficiency of aldosterone will lead to sodium loss and excess potassium in the bloodstream. Certain autoimmune diseases, such as multiple sclerosis and lupus, run in families. The most common symptom is muscle weakness, which worsens with activity and improves with rest. When your healthcare provider interviews you, they might ask you one or more of the following questions: There are no cures for autoimmune diseases, but symptoms can be managed. Autoimmune diseases are more common in women and often run in families. Some examples of medications used to treat autoimmune diseases include: Some people try complementary (alternative) medicines and procedures. While considered a taboo subject by some, many women have their lives affected by . Some conditions may be serious, and self-diagnosis can put a person at risk of improper treatment. Ledderhose disease can be treated through nonsurgical or surgical methods. Gonalves Schrder e Souza B, et al. They may offer online and in-person resources to help people live well with their disease. Some diseases are genetic they run in families. Tracheal deviation can be caused by various conditions. A small collection of bumps on the bottom of your foot. Participating in research helps researchers ultimately uncover better ways to treat, prevent, diagnose, and understand human diseases. If you have Ledderhose disease, small, hard nodules develop slowly on the bottom of your feet. Cryosurgery is another treatment option. It may not be possible to prevent autoimmune diseases. [6], Plantar fibromatosis is most frequently present on the medial border of the sole, near the highest point of the arch. They build public awareness of the disease and are a driving force behind research to improve patients' lives. [5], MRI and sonogram (diagnostic ultrasound) are effective in showing the extent of the lesion, but cannot reveal the tissue composition. People with celiac disease cant eat foods containing gluten, a protein found in wheat, rye, and other grain products. Epub 2018 Jan 9. Results from the Swiss prospective observational cohort. A 2015 study noted that celiac disease affects about 1% of people in the United States. Muscles that control eye movements, eyelid opening, swallowing, and facial movements are often involved. For how long? Cleveland Clinic is a non-profit academic medical center. It is histopathologically associated with Dupuytren's disease. High blood sugar results can damage the blood vessels and organs, including the heart, kidneys, eyes, and nerves. Other diseases, like systemic lupus erythematosus (SLE), or lupus, can affect the whole body. There are only three reported cases of polyfibromatosis and keloids with erosive arthritis. Get useful, helpful and relevant health + wellness information. Its helpful to have some questions ready to ask before you see your provider. Accessibility The disease is a chronic fibrotic condition that usually affects the skin underneath the palms, which eventually leads to the formation of knots, nodules, and cords. eCollection 2021. The comorbidity between Celiac disease and other autoimmune disorders has been studied extensively and clearly established. The true cause of this condition is not known but some professionals think . Federal government websites often end in .gov or .mil. Called autoimmune disease, these attacks can affect any part of the body, weakening bodily function and even turning life-threatening. Abstract Ledderhose disease or plantar fibromatosis is a rare hyperproliferative disorder of the plantar aponeurosis, clinically characterized by nodules situated especially on the medial border of the foot. Lesions may be symptomatic because of a mass effect or invasion of adjacent muscles or neurovascular structures. Should I let my family members know that I have an autoimmune disease? [citation needed], A combination of physical examination of the arch and plantar fascia, as well as ultrasound imaging by a physician is the usual path to diagnosis. Symptoms may develop over time and include: 9 Fatigue, exhaustion, and lack of motivation Jaundice , which is yellowing of the skin and eyes Joint pain Nausea and vomiting A period of symptoms is called a flare-up. Type 2 Diabetes: Is It an Autoimmune Disease? [citation needed], An MRI Scan (Magnetic Resonance Imaging) is usually the imaging of choice to determine between other possible conditions such as ganglion cysts. Already having one autoimmune disease. Before moving a condition from here to the list of autoimmune diseases, references should be provided in the Wikipedia page for the condition that point to . Examples include: The specialist you need depends on the type of autoimmune disease you have. The pain and feeling of a lump in your foot can make it hard to stand or walk. What Is This Lump on the Side of My Foot? A positive test means you may have one of these diseases, but it wont confirm exactly which one you have or if you have one for sure. Sudden weakness, especially if you cant move. Ledderhose disease is a type of plantar fibromatosis characterized by the growth of hard and round or flattened nodules (lumps) on the soles of the feet. On darker skin, psoriasis can appear purplish or dark brown with gray scales. Andres E, et al. Infiltration of auto-reactive lymphocytes in thyroid . A physical therapist may recommend specific exercises based on the location and size of the nodules. Your symptoms will be easier to manage if the condition is treated promptly. These lumps form along the plantar fascia the band of tissue that connects your heel bone with your toes. [7] There has also been variable success in preventing recurrence by administering gadolinium. The femoral artery is one of the major arteries in the human body. Resource(s) for Medical Professionals and Scientists on This Disease: Symptoms of this disease may start to appear as an Adult. A Western diet is another suspected risk factor for developing an autoimmune disease. What activities should I avoid? National Center for Advancing Translational Sciences. Would you like email updates of new search results? Its like it can no longer tell the difference between whats healthy and whats not between whats you and whats an invader. This damage can lead to numbness, weakness, balance issues, and trouble walking. The immune system is involved, but not exactly like an autoimmune disease. [2] Occasionally, the nodules may lie dormant for months to years only to begin rapid and unexpected growth. Too little cortisol can affect how the body uses and stores carbohydrates and sugar (glucose). In Plymouth the Orthopaedic Hand Surgery Unit in Derriford Hospital offers treatment for Dupuytren's, with Mr Jacob Manushakian and Ms Fullilove the hand specialists. Doctors dont know exactly what causes the immune system to misfire. That means that your treatment must be unique. You can treat Ledderhose disease in its earliest stages with shoe inserts, massages, stretching, ice and over-the-counter medications. Your healthcare provider may refer you to a: Some experts say that what you eat affects autoimmune diseases. Your physical therapist can recommend stretching exercises, massage your feet, and give you splints to relieve the hard growths. 2022 Jul 13;12(7):1705. doi: 10.3390/diagnostics12071705. Autoimmune arthritis happens when your immune system attacks the lining of your joints. Myasthenia gravis affects nerve impulses that help the brain control the muscles. De Souza, D.F., Micaelo, L., Cuzzi, T., & Ramos-e-Silva, M. (2010, September). Ultrasound and magnetic resonance imaging are used to confirm the diagnosis and to eliminate other disorders. Last reviewed by a Cleveland Clinic medical professional on 05/16/2022. (2014). Understanding Psoriasis in Children: Symptoms, Treatments, and More, numbness and tingling in the hands and feet. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. eCollection 2020 Apr. There are more than 80 autoimmune diseases. Youre at a higher risk of developing another. But, some experts recommend that you try: Your autoimmune disease symptoms may change with time. Drugs that suppress (subdue) your immune system. Even with successful treatment, there is no guarantee that the nodules will not come back over time. Treatment is for correction of deformity from Dupuytren contracture. An autoimmune disease is the result of the immune system accidentally attacking your body instead of protecting it. Find resources for patients and caregivers that address the challenges of living with a rare disease, Learn more about the different types of clinical studies, ResearchMatch helps connect people interested in research studies, UMLSVocabulary Standards and Mappings Downloads, Access aggregated data from Orphanet at Orphadata, National Center for Biotechnology Information's, Newborn Screening Coding and Terminology Guide, Improving newborn screening laboratory test ordering and result reporting using health information exchange, Health Literacy Online: A Guide for Simplifying the User Experience, U.S. Department of Health & Human Services, National Center for Advancing Translation Sciences, Ways to connect to others and share personal stories, Up-to-date treatment and research information, Lists of specialistsor specialty centers. Note, GARD cannot enroll individuals in clinical studies. Systemic lupus erythematosus (Lupus, SLE). Eaton et al. (2017). A subtype is a more specific clinical definition of the main disease. Experts dont know why your immune system turns on you. Learn more about the causes, symptoms, and treatment of plantar fasciitis here. It is histopathologically associated with Dupuytren's disease. Learn about psoriasis triggers, medications, and coping, Juvenile idiopathic arthritis is the most common type of arthritis in children. Furthermore, any treatment method should be discussed with a doctor beforehand. People with Ledderhose disease may also have other conditions associated with the formation of excess fibrous connective tissue such as Dupuytren contracture, knuckle pads, or Peyronie disease. The Difference Between Rheumatoid Arthritis (RA) and Lupus, Crohns Disease vs. UC: Exploring Different Types of IBD. If these treatments dont work and the lump is very painful, your doctor might recommend a type of surgery called fasciectomy. Notice the development of growths or bumps near the middle of the bottom of your feet. The symptoms you have will depend on the body part (s) affected, such as: Joints, which can cause joint pain, stiffness, and loss of function. No single test can diagnose most autoimmune diseases. Have you had to go to the emergency department because of your symptoms? However, it seems to occur in those who have other types of fibromatosis. It is approximately 80% effective, with minimal side-effects. The extra cells build up and form inflamed, red patches, commonly with silver-white scales of plaque on lighter-toned skin. The success rate for this surgery is mixed, as the disease can eventually come back. The growths arent cancerous, but they can cause pain, especially when you walk. All rights reserved. Reference: Data from the Newborn Screening Codingand Terminology Guide is available here. Autoimmunity and the gut. Small vessel disease occurs when the small arteries cant get enough oxygen to the heart. In rare cases, your toes may curl down toward the bottom of your feet. MNT is the registered trade mark of Healthline Media. Your feet may become swollen, and the growths on your feet may be painful. The primary symptom of Ledderhose disease is hard lumps on the soles of one or both of your feet. Symptoms of Ledderhose disease may include: Healthcare providers dont know what causes Ledderhose disease. Which autoimmune diseases run in your family? In some, the alternative name is actually a subtype. Ledderhose Disease can be pain-free, but especially as the fibromas get larger, many patients experience a considerable amount of pain standing and walking on the affected foot. Although they cant be cured, some of the symptoms can be treated. Common ones include lupus, rheumatoid arthritis, Crohn's disease and ulcerative colitis. Having another autoimmune disease such as rheumatoid arthritis, type 1 diabetes or lupus increases your risk of developing Hashimoto's disease. /. You might need to visit a specialist, depending on the type of disease you have. Ledderhose disease: an unusual presentation. Treatments include medications to calm the overactive immune response and bring down inflammation in the body. It's unclear why your immune system does this. Healthline has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical associations. When it senses these foreign invaders, it sends out an army of fighter cells to attack them. The number and severity of symptoms experienced may differ among people with this disease. Because doctors dont know exactly what causes Ledderhose disease, it may not be possible to prevent. The thyroid is a small, butterfly-shaped gland in the front of your neck. There are more than 80 autoimmune diseases. 2020 Apr 27;8(4):e2754. These treatments include: If your pain doesnt decrease or stop after several months of conservative treatment, your healthcare provider may suggest the following: In many cases, you should feel better after several weeks of proper treatment. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation, mask requirements and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Take steps toward getting a diagnosis by working with your doctor, finding the right specialists, and coordinating medical care. A disease in which the immune system unintentionally attacks your body is an autoimmune disease. One million people in the U.S. have lupus and 1.4 million have Crohns disease or ulcerative colitis. Autoimmune disease is often misunderstood. During a massage, it is important to avoid the nodules themselves, as they can be very painful when touched. Although the causes of many autoimmune diseases remain . The world incidence and prevalence of autoimmune diseases is increasing. Dietary intolerances are found in both diseases. When this connective tissue thickens, it can clump together and form tough nodules. Anything that makes them worse? Singapore Med J. The immune system usually guards against bacteria and viruses. Because healthcare providers dont know what causes Ledderhose disease, it may not be possible to prevent it. However, the procedure can cause complications such as: Treatments can improve the symptoms of Ledderhose disease. Brooke Burke doesn't want people to judge a book by it's cover. 50.1 ). (2014). Ledderhose disease or plantar fibromatosis is a rare condition affecting the bottom of the feet. However, there are risk factors that may increase your chances of getting an autoimmune disease. The etiology, evaluation, and management of plantar fibromatosis. Lerner A, et al. [citation needed], Cortisone injections, such as Triamcinolone,[4] and clobetasol ointments[9] have been shown to stall the progression of the disease temporarily, although the results are subjective and large-scale studies far from complete. Although doctors in the 1800s first described lupus as a skin disease because of the rash it commonly produces, the systemic form, which is most common, actually affects many organs, including the joints, kidneys, brain, and heart. Ledderhose disease, sometimes called plantar fibromatosis or "Dupuytren's of the foot," is characterized by lumps called nodules on the underside of the foot. Type 1 diabetes The pancreas produces the hormone insulin, which helps regulate blood sugar levels. Though it is benign, Ledderhose disease may also be linked to other forms of fibromatosis, including Dupuytrens or Peyronie disease. Fri Mar 3 2023 - 06:01. "Dupuytren's Disease and Related Hyperproliferative Disorders" (Springer, Heidelberg & New York, 2012) p 409-428. These are caused by a thickening in the deep connective tissue (the fascia) in the foot and can cause discomfort or pain when walking . [6] 5 Ways to Increase Nitric Oxide Naturally, What You Need to Know About Leukocytoclastic Vasculitis. Pleurodesis is a procedure to adhere your lungs to your chest wall. Plantar fibromatosis/Ledderhose disease (LD) is a hyperproliferative non-malignant disorder of unknown cause with low incidence rate of 1-2 cases per 100,000 hospital admissions (Ledderhose 1897; Pickren et al. In Ledderhose disease (described in 1897), as in Dupuytren contracture (DC) (first reported in 1831), repeated trauma, long-term alcohol consumption, chronic liver disease, diabetes, and epilepsy have been reported in association with the development of the lesions in middle-aged or elderly people. Ledderhose Disease: Clinical, Radiological (Ultrasound and MRI), and Anatomopathological Findings. It is thought that if you have this disease, you may have genetic markers or family history that put you at a higher risk of getting it. This condition attacks the glands that provide lubrication to the eyes and mouth. An official website of the United States government. Young JR, Sternbach S, Willinger M, et al. Expert Answers: Ledderhose disease, sometimes called plantar fibromatosis or "Dupuytren's of the foot," is characterized by lumps called nodules on the underside of the foot. Barrie WE. Doctors can often identify the disease based on the type of nodule a person has. Treatments cant cure autoimmune diseases, but they can control the overactive immune response and bring down inflammation or at least reduce pain and inflammation. Ledderhose disease often affects those who have: Ledderhose disease affects less than 200,000 people in the United States every year. Physical therapy is often recommended for cases of Ledderhose disease. During sessions, physical therapists may massage the feet and give someone splints to help relieve the nodules. Rheumatoid arthritis and lupus are autoimmune diseases that share some symptoms but also have important differences. A foot rash may occur due to an allergic reaction or infection. Lupus (SLE), a systemic issue that affects the skin, joints, kidneys, brain, and other organs and can manifest in fatigue, joint pain, fever, and a rash. Pernicious anemia is more common in older adults. Stay in touch with your healthcare provider about any advances in understanding and treating autoimmune diseases. Get useful, helpful and relevant health + wellness information. The nodules are usually painless at first but may grow and cause discomfort or pain. Many people with autoimmune diseases can live a normal life. Bethesda, MD 20894, Web Policies They will: Your healthcare provider may conduct the following tests to diagnose Ledderhose disease: Your regular healthcare provider can diagnose and treat the earliest stages of Ledderhose disease.
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