The present research work explores the chemical and biological characterization of one of the most common species of this genus, i.e., Calotropis gigantea (L.) Dryand (syn. PDF 10.19080/GJPPS.2017.03.555601 Wound Healing Potential of ... This particular study emphasis on the in vivo wound healing and in vitro antibacterial activity of herbal lotions preparated from Ethanolic extract of Justicia tranquebariensis, Aloe vera and Curcuma longa. Keywords: Bixa orellana, Atsuete, Burn wound, Ointment, Ethanolic 1. Ipomoea carnea Five groups of adult male Sprague Dawley rats were experimentally wounded in the posterior neck area. Samples of 42 female mice were divided into three groups: group I - methylcellulose (negative control); group II - 0.5% (w/w) crude extract; and group III - 1.5% (w/w) crude extract. Applied to wounds for over 5000 years by Egyptians, Romans, indigenous peoples of Africa Asia, and the Americas, Aloe vera continues to be a first-line treatment for burns, ulcers, and surgical wounds [ 34 ]. The ethanolic extract of leaves of Calotropis gigantea . (Asteraceae) was evaluated on excision, incision, and dead space wound models in rats. In order to evaluate the wound healing activity of A. vasica, five different solvent extracts were prepared from the leaves of the plant. These agents usually influence one or more phases of the healing PDF Effect of Achillea millefolium extract in wound healing of ... extract of A. africana indicates that the plant extract possesses wound healing properties even when formulated in gels. compared to hydroalcoholic extract. Evaluation of Antibacterial and Wound Healing Activity of ... The biological and physical augmentation provided by extracellular matrix derived implants continues . The current study was aimed at investigating the wound healing capacity of Aristolochia saccata leaf extract by using scratch assay as a primary model, where proliferative and migratory . Objective: To evaluate the wound healing activity of the leaf extracts and deoxyelephantopin isolated from Elephantopus scaber Linn. In the current times, different types of biopolymers are being researched for . Wound Healing with Natural Products: Effective Plant-Based ... [PDF] Electrospinning of Crude Plant Extracts for ... Wound healers, Wound healing medicinal plants. Acanthus polystachyus is one of the medicinal plants used traditionally for treatment of wounds. It applies as an antioxidant, anti-inflammatory, anti-lithiasis, and anti-diabetic. by single oral dose. The healing of wounds often deviates from normal course, under-healing, over-healing or failure of wounds [1]. The anticancer activity was performed using cancerous human cell lines (HepG2, Caco-2, A549, MDA-MB-231, and NCI-H1437 carcinoma cells), while the . Scaffolds can be prepared by choosing proper polymer and extract types which are combined to get unique properties of scaffolds to lead an innovative and eco- friendly approach in wound treatment applications. Polymeric biomaterials can be used to hydrate the wound and serve as barrier to pathogens with plant extracts, antimicrobial agents and extracellular components incorporated to stimulate the healing process. The result of this study attested that the leaves of mayana can be utilized as a source of herbal plant, specifically to heal wounds. Methanol, ethanol, ethyl acetate, chloroform and hexane were used for the extraction of the active ingredients. The different agents are used in order to wound healing including antibiotics and antiseptics, desloughing agents (chemical debridement, e.g., hydrogen peroxide, eusol and collagenase ointment, wound healing promoters, some substances such as tissue extracts, vitamins, and minerals and a number of plant products . Wound healing is a process by which tissue regeneration occurs. Plants have arrays of phytoconstituents that have wide ranging biological effects like antioxidant, anti-inflammatory and antimicrobial properties key in wound management. Facile preparation of silver-loaded nanofilm for wound healing (i) preparation of plant extract; (ii) Fabrication of AgNPs using plant extract as a reductant for silver nitrate; (iii) Blending of . Indeed, new treatments accelerating wound closure and at the same time preventing infections present a great interest, particularly in tropical area. Electrospun nanofibers provide high porosity with large surface area-to-volume ratio and are more appropriate . Each plant powder (10 g) was soaked in 30 ml of ethanol in a sterile bottle for 48 h at 4 °C. Calendula is rich with antioxidants and increases blood circulation at the wound site, which promotes healing. 2.6.1 Excision wound An area was marked on the depilated back of the rat by a standard ring, and an excision wound was inflicted by cutting The percentage of wound closure was 90.0% in the extract-treated group, whereas the control group showed only 51.1% on the eighth day of wounding (p < .01). Crude extracts of this plant have been found to possess antihyperglycemic, antidyslipi- Electrospinning of Crude Plant Extracts for Antibacterial and Wound Healing Applications: A Review @inproceedings{Khan2018ElectrospinningOC, title={Electrospinning of Crude Plant Extracts for Antibacterial and Wound Healing Applications: A Review}, author={Atta Ur Rehman Khan and Shi Xiangyang and Aftab Ahmad and Xiumei Mo}, year={2018} } In our present investigation, all the extracts prepared from leaf (acetone, water, and . Wound . Acanthus is a genus of owering plants belonging to thefamilyAcanthaceae.e Acanthus familyisfairlylarge with some - species in about genera. This study aims to examine the wound healing potential of P. suaveolens leaves extract as well as scientific clarify of the plant. The aqueous extract was studied at dose level of 300 mg/kg body weight using resutured incision; excision and dead space wound models in rats. (Family: Convolvulaceae) is well known herb extensively used in folk medicine in India. The plant extracts comfrey, calendula and yarrow have also shown some efficacy in wound healing. Plants and their extracts have immense potential for the management and treatment of wounds. This study investigates the wound healing properties of P. americana leaves extract on Mus musculus in gel formulations. The reduction in epithelization time of experimentally-induced wound by the extract of the plant has been described [7]. Antioxidant activity: The study showed that the leaf extracts of J. curcas formulated into ointment base is good for wound care and healing activities. In vitro cell based scratch assay is an appropriate and inexpensive method for initial understanding of wound healing potential of medicinal plant extracts. 100% wound healing, achieved after 14 days of treatment with 5% yarrow extract cream. Priya KS, Arumugam G, Rathinam B, Wells A, Babu M. 2004. Discussion Healing of wound is a complex phenomenon involving various phases e.g. As this study, published in the Journal of Medicinal Food, suggests, "despite the discovery of antimicrobial agents, antiseptics, and anti-inflammatory drugs, the wound closure process is challenging in the clinical setting of modern medicine. Poikilospermum suaveolens is a plant could grows in the limestone area in Maros, Indonesia. The wound healing effect of 5% yarrow extract cream was more pronounced as compared to 1% phenytoin (Fig 3). Journal of medicinal plants research 2(1), 1011-6. To assess healing activity of aqueous and ethanolic root extracts of Strophantus gratus (AESG and EESG), standard models of excisional and incisional wounds were used. Wong et al. The wound-healing activity was assessed by the . Traditionally, plants of the genus Calotropis have been used to cure various common diseases. 4. Scientific reports on medicinal plants that are positively affecting various healing stages such as coagulation, inflammation, epithelization and collagenization are widely available in well-known biomedical databases such . Keywords: Wound, wound healing, Ficus religiosa, Ficus benghalensis Introduction Wounds are inescapable events of life, which arise due to physical or chemical injury or microbial infections. Leung1,5 In chronic nonhealing wounds, the healing process is disrupted and wounds are often . leaf contains two major compounds that, either alone or in addition with the minor components present in the plant extract, can trigger the cellular events, critical to wound healing. I. Suntar. Expand. Moreover, in Cameroon and Madagascar, pounded bulbs are applied to abscesses, boils, and wound infections [10]. The days needed for re-epithelization were 17.7 for the control animals; extract treatment at a dose of 20 or 100 mg/kg b.wt reduced the period to 14 and 13 days, respectively. by single oral dose. Hydroxyapatite (0.5 g) was stirred with 98 mL distilled water until complete dispersion, followed by the addition of plant aqueous extract (in two concentration 2 % and 5 %). 4.1. Others have reported related functions that may contribute to tissue repair, namely, immunomodulation [ 275 ], antioxidation [ 276 ], hepatoprotection [ 277 ], radioprotection [ 278 ], and anticancer [ 279 . Ethanolic extracts of rhizomes from Rhodiola imbricata stimulate a robust wound healing response when applied to excisional wounds in rats . The result revealed that the leaves of mayana has wound healing property in Albino Rats. physiological process can result in a non healing wound because of net destruction of soluble growth factors and matrix elements 32, 33. Comfrey - used topically as an ointment or cream - is good for treating bruises but should not be used on an open wound. The development of nanotechnological methods can help to improve the efficacy of different therapeutics as well as herbal-based products. Use of plant extracts for treatment of burns and wound is a common practice followed over the decades and it is an important aspect of health management. For testing presence of alkaloids, Ammonia solution (3 mL) was added to Bidens pilosa powder (1 g) and An extract-free formula was used as blank. Materials and Methods: The effect of aqueous ethanol extracts and the isolated compound deoxyelephantopin from E. scaber Linn. The plant extracts comfrey, calendula and yarrow have also shown some efficacy in wound healing. Wound healing is a natural process that enables tissue repair after an injury. In conclusion, our data propounds that 32% ethanol extract of Annona reticulata Linn. Caesalpinia mimosoides extract contains phenolic contents and has a remarkable antioxidant activity leading to the enhancement of the wound healing property [10]. hitherto unknown wild plants for treating wounds and burns (Kumar et al., 2007). Phytochemically the plant has been reported to contain sesquiterpene lactones deoxyelephantopin, isodeoxy-elephantopin, and scabertopin. Wound healing is the key to repair of skin damage, and the application of wound dressing can effectively improve wound healing. Calotropis gigantea (L.) Dryand. One plant used traditionally in wound treatment is Pupalia lappacea. Aims and Objectives: The objective of this research study is to evaluate the wound-healing potential of the plant extract on mouse fibroblast cell line L929 through scratch assay and the potential effect of the plant extract on the expression of two key wound-healing factors, fibronectin and . The plant leaves were extracted by maceration. For testing the wound healing activity, the methanolic extracts of the plants were used at 5% and 10% in paraffin vehicle and the effect was compared with the wound healin significant toxicity after oral dosing Introduction Wound is defined as disruption of cellular, anatomical, and functional continuity of a Caesalpinia mimosoides extract contains phenolic contents and has a remarkable antioxidant activity leading to the enhancement of the wound healing property [10]. A Review on Medicinal Plants with Potential Wound Healing Activity. coagulation, inflammation, collagenation, wound contraction Among the natural products extracted from the plants that have demonstrated biological activities, some of them need to receive particular attention as antimicrobial and wound healing agents [5,6]. For testing the wound healing activity, the methanolic extracts of the plants were used at 5% and 10% in paraffin vehicle and the effect was compared with the wound healin significant toxicity after oral dosing Introduction Wound is defined as disruption of cellular, anatomical, and functional continuity of a Excision wound model on Swiss albino mice was used to assess the wound healing activity of the . Many medicinal plants are claimed to be useful for wound healing in the traditional system of medicine. The process of wound healing consists of integrated cellular and . Plant based scaffolds augments wound healing and provide better tissue regeneration with minimal negative effect on skin. However, there were no scientific reports documented so far on the wound healing activities of this plant. A. africana was also reported to possess Comfrey - used topically as an ointment or cream - is good for treating bruises but should not be used on an open wound. Hydroxyapatite (0.5 g) was stirred with 98 mL distilled water until complete dispersion, followed by the addition of plant aqueous extract (in two concentration 2 % and 5 %). The development of nanotechnological methods can help to improve the efficacy of different therapeutics as well as herbal-based products. Corpus ID: 212442878. Medicinal plants are known for their diverse use in the traditional medicine of the Himalayan region of Pakistan. The phyto-medicines for wound healing . complete wound healing (100.00% wound contraction). The leaves are generally widely used as traditional medicine for treatment of wounds by local communities. The process of wound healing is promoted by several natural plant products, which are composed of active principles like flavonoids, tri-terpenes, alkaloids, tannins and other biomolecules. Natural plant extracts can be beneficial for wound healing if their phytochemical has the antioxidant activities and free radical scavengers, as reported by many previous studies [5]. To shorten its duration and minimize associated complications, wounds are treated with medications. Bio-synthesized TiO 2 NPs by using Moringa oleifera Lam. Preparation of plant extract-loaded hydrogel formula for in vivo wound healing study. Celosia argentea Linn. plant are commonly used to treat wounds and tiger bites (Kaul et al. Historically, plants and plant-based constituents have been extensively used for the treatment and management of different types of wounds. The anti-inflammatory activity of the roots of j . Traditional Use of Medical Plants in Wound Healing. [14]. Among the various wound healing plants, I. carnea Jacq. Aloe vera. Biomaterials are constructed to promote or stimulate the processes of wound healing. Wounds are…. In vivo wound healing properties of ointments made of crude methanolic extracts (10% extract w/w in white soft paraffin) of three plant species, Cissus quadrangularis L. (whole aerial plant parts), Adenium multiflorum . Throughout history, compounds have been used from nature to assist with wound closure. Various plant products have been used in treatment of wounds over the years. The effects of medicinal plants on wound healing may be linked to the free radical scavenging action of compounds in the extracts acting either singly or synergistically . Research Feed. leaf extract were capable of enhancing wound healing activity in Albino rats showing 92.36% of healing. In order to be included, publications had to deal with an assessment of plants in vitro, ex vivo, in vivo or in a clinical trial and/or the topical use of plants and/or their extracts AND antimicrobial (antibacterial, antiviral or anti-mycotic) effects, anti-inflammatory effects, astringent effects, wound healing, epithelial proliferative or . Hence, based on the evidence of such traditional practice as medicine, the present study was designed to scientific-ally validate the wound healing efficacy of topical and oral admin-istration of P. fulgens root extract and its polyphenolic rich fraction in experimental . The present study is designed to investigate the anticancer and antimicrobial activities of Prunus cornuta and Quercus semicarpifolia. Aloe vera, as an ancient medicinal plant, has attracted the attention of researchers because of its remarkable effect on wound healing. Abstract: Background: Clerodendrum inerme is a medicinal plant which exhibited many pharmacological effects.However, wound healing property of this plant has not been investigated. Background . Several plant extracts and their phytoconstituents are known as a promising alternative for wound healing agents due to the presence of diverse active components, ease of access, and their limited side effects. The Medicinal Value of Asteraceae Family Plants in Terms of Wound Healing Activity. Introduction Wounds can be caused by a lot of factors including pressure, mechanical abrasions and trauma, aqueous extract of C. papaya leaves were investigated for evaluation of wound healing potential in rats. (2001) reported in their study that amputation could be avoided in 87% of diabetic wound using Chinese herbal medicine [ 31 ]. Significant increase in wound closure rate, skin-b … Medicinal plants heal wound . Calendula is rich with antioxidants and increases blood circulation at the wound site, which promotes healing. the Use of root extracts such as root oil is recorded to have been used by the Chinese for over two millennia, to aid in nausea, vomiting, and even memory loss. These plant remedies (both single plant and multiherbal reparations) are used since ancient times even though the mechanism of action and efficacy INTRODUCTION. "Plants and natural extracts that have been used in . Currently there is a growing interest in the use of alternative wound dressing agents such as plant extracts Popular medicinal use of coconut husk fibre have been reported , hence the study was undertaken to evaluate the antibacterial and wound healing activity of Cocos nucifera (coconut) husk ash extract in mice. Wound is defined simply as the disruption of the cellular and anatomic continuity of a tissue (Bennet, 1988). Various traditional texts and animal studies indicate the anti-inflammatory effect of plant extract thus can be used as wound healer drugs 34, 35. Persea Americana Mill. . 3. (avocado) is the dicotyledonous plant that rich in secondary metabolite compounds such as saponins, alkaloids, terpenoids, and flavonoids. Evaluation of the Wound Healing Activity of the Crude Extract of Leaves of Acanthus polystachyus Delile (Acanthaceae) . Preliminary phytochemical . INTRODUCTION formulation in the market which can claims for its wound healing Wound may be defined as a disruption of the cellular and anatomic continuity of a tissue, with or without microbial infection and is produced due to any accident or cut with sharp edged things. 2.2.3 Phytochemical screening of the extracts: The plant extract of Bidens pilosa was screened for presence of compounds that are essential in wound healing (alkaloids and flavonoids) following methods described by Hossain et al. wound healing, medicinal plant, proliferation, tissue healing, skin. Aqueous extract of leaves of M. oleifera was investigated and rationalised for its wound healing activity. The healing or wound contraction elicited by Saba florida leaf extract in this investigation following topical and oral administration strongly support the verbal claim of traditional doctors on the use of this plant. Electrospinning Process The results were compared among treatments and a control group, in terms of . 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